|
| Catalog Number | Size | Price (USD) | Shopping Cart |
|---|---|---|---|
| GT15136 | 100 ug | $365.00 | Buy Now | Add to Cart |
Type: Goat IgG
Applications: WB; E
ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; All Fluorecent Images;
Species Reactivity: H
B=Bovine; Ca=Cat; Ch=Chicken; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Ze=Zebrafish; na
Format: Affinity Purified - liquid
Immunogen: NS0-derived rhBACE-1
Description/Data:
BACEs (Beta-site APP-Cleaving Enzymes), also named β-secretases, are membrane-bound aspartic proteases of the pepsin family. BACE-1 is the principle beta-secretase responsible for cleavage of amyloid precursor protein (APP) and, therefore, is a potential target for treatment of Alzheimer's disease. BACE-1 is widely expressed and likely has additional functions including the liberation of a membrane-bound sialyltransferase.
It is important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells.