Bcl-w

Affinity Purified Goat Antibody

DATASHEET (pdf - 163Kb)

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Type: Goat IgG

Applications: IHC

ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; All Fluorecent Images;

Species Reactivity: H; M

B=Bovine; Ca=Cat; Ch=Chicken; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Ze=Zebrafish; na

Format: Affinity Purified - liquid

Immunogen: Purified, E. coli-derived, recombinant human Bcl-w (rhBcl-w).

Description/Data:

Bcl-w is a pro-survival (anti-apoptotic) member of the Bcl-2 family; a family involved in the regulation of cellular apoptosis at the mitochondrion. Relative to its Bcl-2 counterparts there is considerably less data on this prticular protein.

Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis.

Image: Bcl-w staining of paraffin-embedded human spleen tissue sections. Tissues were stained using HRP-DAB (brown) and counterstained with hematoxylin (blue).

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