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| Catalog Number | Size | Price (USD) | Shopping Cart |
|---|---|---|---|
| RA30036 | 50 ug | $365.00 | Buy Now | Add to Cart |
p38 MAP Kinase (p38 Alpha), a MAPK type protein kinase, is an environmental stress- and inflammatory cytokine-induced kinase that is associated with the regulation of gene expression, cell proliferation and cell death.
p38 alpha is phosphorylated by MEK3/MAP2K3 or MKK6/MAP2K6. Activated p38 alpha either remains in the cytosol, where it phosphorylates cytosolic proteins including MNK1/2, PLA2 and PRAK, or translocates to the nucleus, where it phosphorylates several substrates, including ATF2, CHOP/GADD153, MAPKAPK-2 and -3, MEF2-A and -C, MSK, Myc binding partner Max and Sap-1a. At least four protein isoforms, resulting from alternatively spliced transcript variants of this gene, have been identified - 297, 307 and two isoforms of 360 amino acids with differing internal segments.
Image: p38 MAP Kinase staining of Human Heart Tissue. Paraffin embedded.