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| Catalog Number | Size | Price (USD) | Shopping Cart |
|---|---|---|---|
| RA14132 | 100 ul | $350.00 | Buy Now | Add to Cart |
c-Kit is transmembrane tyrosine kinase encoded by the c-Kit proto oncogene. c-Kit acts to regulate a variety of biological processes including cell proliferation, apoptosis, chemotaxis and adhesion.
It plays a critical role in activation and growth in a number of cell types such as hematopoietic stem cells, mast cells, melanocytes and germ cells.
Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.
Image: c-KIT staining of rat skin (epidermis). c-KIT detection was done using anti-rabbit Cy3 conjugated antibodies (red color). DAPI was used to counterstain cell nuclei (blue color).Working dilution: 1:100-1:300.
c-Kit: Customer Publications
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c-Kit staining of mouse skin.