proDynorphin

Dynorphin peptides are members of the opioid peptide family and contain the canonical opioid sequence Tyr-Gly-Gly-Phe. These peptides are derived from prodynorphin and include dynorphin A, dynorphin B and alpha neo-endorphin. Of the opioid peptides, the dynorphins have the highest affinity for the kappa opioid receptor. They are found distributed throughout the nervous system and play a role in many physiological functions.

Please note: Dr Patrick Mantyh et al have successfully used this amtibody to stain mouse spinal cord tissue. see J Pain Symptom Manage. 2008 September; 36(3): 289–303.

Pro-Dynorphin: Customer Publications

Images: Systemic artemin normalized immunohistochemical markers in the ipsilateral L₅ DRG, dorsal spinal cords and sciatic nerves of SNL rats.Immunofluorescent labeling was done 14 d after sham or SNL surgery and treatment with vehicle or artemin starting on day 3 after surgery. Scale bar = 100 um for DRG (first two rows), 50 m for sciatic nerve (third row) and 200 m for spinal cord (bottom row). Nature Medicine  9, 1383 - 1389 (2003); doi:10.1038/nm944 ...guinea-pig antibody to prodynorphin (1:10,000; Neuromics). Secondary antibodies were Alexa Fluor 594−conjugated goat antibody to guinea-pig IgG (1:1,000; Molecular Probes)...

Image: Immuofluorescent detection of Prodynorphin (seen as immunoreactive varicosities) in art hypothalamus (red fluorescence).