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| Catalog Number | Size | Price (USD) | Shopping Cart |
|---|---|---|---|
| RA19015 | 100 ug | $225.00 | Buy Now | Add to Cart |
Type: Rabbit IgG
Applications: WB
ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; WB=Western blotting; FC=Flow Cytometry; IP=Immunoprecipitation; E=ELISA; NB=Neutralization of Bioactivity; FACS; All Fluorecent Images;
Species Reactivity: H; M; R
B=Bovine; Ca=Cat; Ch=Chicken; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Ze=Zebrafish; na
Format: Affinity Purified - lyophilized
Immunogen: ERLLREYPQSFEKGV of the N terminus of SHANK1a
Description/Data:
Shank is a novel family of postsynaptic density proteins (PSD) that bind to PSD-95-associated protein GKAP. Its putative function is to act as a scaffold protein in the PSD to cross-link NMDA receptors/PSD-95 complexes and couple them to regulators of the actin cytoskeleton. Shank1a is a splice variant of Shank1.
Shank1 A has also been found to be associated with L-type Ca2+ channels. Olson et al., J Neurosci. 2005, 25:1050-62; Zhang et al., J Neurosci. 2005, 25:1037-49) the same channels used by photoreceptors for transmitter release.