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| Catalog Number | Size | Price (USD) | Shopping Cart |
|---|---|---|---|
| PR27004-2 | 2 ug | $75.00 | Buy Now | Add to Cart |
| PR27004-10 | 10 ug | $175.00 | Buy Now | Add to Cart |
Type: Protein
Species Reactivity: H
B=Bovine; Ca=Cat; Ch=Chicken; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Ze=Zebrafish; na
Description/Data:
ProNGF is the pro-form of the neurotrophin nerve growth factor. Like the mature protein proNGF is characterized by the cysteine knot motif consisting of three cysteine bridges. The protein predominantly exists as a non-covalently linked homodimer.
Technical Note: The proNGF is a 50 kDa dimer in solution, on SDS-PAGE monomer at about 25-30 kDa is detected. To analyze this protein on an SDS-PAGE., DTT as a reduction agent is absolutely necessary.
Image: ProNGF protein structure and sequence
References:
1. Forever young?: nerve growth factor, sympathetic fibers, and right ventricle pressure overload. Circ Res 2007 Jun 22;100(12):1670-2
2. Tumor suppressor proteins are differentially affected in human ependymoblastoma and medulloblastoma cells exposed to nerve growth factor. Cancer Invest 2007 Mar;25(2):94-101
3. Axonal growth potential of lumbar dorsal root ganglion neurons in an organ culture system: response of nerve growth factor-sensitive neurons to neuronal injury and an inflammatory cytokine. Spine 2007 Apr 15;32(8):857-63
4. Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells. Spine 2007 Mar 15;32(6):635-42
5. Nitric oxide synthase inhibitors modulate nerve growth factor-mediated regulation of amyloid precursor protein expression in PC12 cells. J Neurochem 2007 Apr;101(2):422-33
6. Biological roles of anti-GM1 antibodies in patients with Guillain-Barre syndrome for nerve growth factor signaling. Biochim Biophys Acta 2007 May;1772(5):543-8
2. Tumor suppressor proteins are differentially affected in human ependymoblastoma and medulloblastoma cells exposed to nerve growth factor. Cancer Invest 2007 Mar;25(2):94-101
3. Axonal growth potential of lumbar dorsal root ganglion neurons in an organ culture system: response of nerve growth factor-sensitive neurons to neuronal injury and an inflammatory cytokine. Spine 2007 Apr 15;32(8):857-63
4. Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells. Spine 2007 Mar 15;32(6):635-42
5. Nitric oxide synthase inhibitors modulate nerve growth factor-mediated regulation of amyloid precursor protein expression in PC12 cells. J Neurochem 2007 Apr;101(2):422-33
6. Biological roles of anti-GM1 antibodies in patients with Guillain-Barre syndrome for nerve growth factor signaling. Biochim Biophys Acta 2007 May;1772(5):543-8
Image: SDS-Page of proNGF