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| Catalog Number | Size | Price (USD) | Shopping Cart |
|---|---|---|---|
| GT15116 | 100 ug | $365.00 | Buy Now | Add to Cart |
Musashi1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Musashi-1 (Msi-1) has been shown to increase the accumulation of tau isoforms in intracellular inclusions in dementia and Parkinson's. The presence of Msi-1 in a significant percentage of neurons containing cytoplasmic inclusions in 2 other neurodegenerative diseases Alzheimer's disease and Pick disease suggests that it may play a role in the pathogenesis of these neurodegenerative disorders.
Musashi1 has also been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in cancer development. Msi-1 also appears to play be an vital role in the development of several types of carcinoma such as human hepatoma, and may be a useful molecular marker for tumor detection.
Image: Musashi-1 immunoreactivity in paraffin-embedded human intestine sections using goat anti-human Musashi-1 affinity-purified polyclonal antibody (HRP-DAB, brown); counterstained with hematoxylin (blue).