ABCA1 and Alzheimer's

ABCA1: Important Protein in Alzheimer's Biology

Image Courtesy of Dr. David Holtzman, Washington Univ.

Anti-ABCA1  (MO13101)

Neuromics has recently released a anti-ABCA1 mouse monoclonal  (Clone HJ1) antibody.  The antibody shows reactivity in mouse, rat, and to a lesser extent human. It appears highly specific in Western blot applications, demonstrated by lack of signal in ABCA1 knockout animals (lane 3).

Background Publications
David Holtzman and colleagues at Washington University in St. Louis have recently published several papers in the Journal of Biological Chemistry.  They demonstrate an important role of ABCA1 in  ApoE regulation.  Its appears that an increase in ABCA1 levels or function may cause a decrease in amyloid deposition via increasing ApoE lipidation. 

The data presented in the papers below suggests a central role for ABCA1 in Alzheimer's biology, leading the authors to speculate ABCA1 as a potential drug target.  

Wahrle SE, Jiang H, Parsadanian M, Legleiter J, Han X, Fryer JD, Kowalewski T, and Holtzman DM (2004). ABCA1 Is Required for Normal Central Nervous System ApoE Levels and for Lipidation of Astrocyte-secreted apoE. J. Biol. Chem. 279(39):40987.

Wahrle SE, Jiang H, Parsadanian M, Hartman RE, Bales KR, Paul SM and Holtzman DM (2005). Deletion of Abca1 Increases Abeta Deposition in the PDAPP Transgenic Mouse Model of Alzheimer Disease. J. Biol. Chem. 280(52):43236.

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