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| Catalog Number | Size | Price (USD) | Shopping Cart |
|---|---|---|---|
| RA14111 | 50 ul | $190.00 | Buy Now | Add to Cart |
| RA14111 | 100 ul | $345.00 | Buy Now | Add to Cart |
| P141111 | 100 ug Blocking Peptide | $95.00 | Buy Now | Add to Cart |
The apelin receptor (APJ receptor) has been identified as the endogenous receptor for the peptide apelin. Previous to the identification of apelin, APJ was considered an orphan G protein coupled receptor. The apelin receptor (both by immunohistochemistry and in situ) has been localized to the CNS and is currently thought to play a role in stress response, feeding behavior and haemodynamic homeostasis. However, because of a broad distribution the apelin receptor and its endogenous ligand may be involved in a wide range of biological process yet to be determined. It is an alternative coreceptor with CD4 for HIV-1 infection and maybe involved in the development of AIDS dementia.
Image: APJ staining of of rat gastric mucosal sections. A: anti-apelin antibody (ab; red pseudocolor). B: anti-HK-ATPase ab (green pseudocolor). C: composite image of green and red fluorescent signals showing that apelin is expressed along with HK-ATPase in parietal cells. D: higher magnification showing red staining of apelin vesicles at the basal site of parietal cells colabeled with HK-ATPase ab (green), showing a separate distribution of the 2 antigens.
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Image: APJ (red) staining of rat brain. Tissue was counterstained with DAPI (blue).