Substance PImage from Dr. Rustioni's Lab, UNC-Chapel Hill Courtesy of Helen Willcockson |
Featured Antibody:
Related Reagents:
Antibodies:
Neurokinin-1 (NK 1) Human Receptor
Neuropeptide and Neuropeptide Receptors
Proteins:
Image: Substance P Staining in Rat DRG Tissue fixed with 4% paraformaldehyde and post fixed for about 2hrs. They are 12um sections cut on a cryostat and thaw mounted onto slides. IHC is done on the slide and we use a 50% alcohol pretreatment(20min) for penetration. Dilution was 1:500. Image from Dr. Rustioni's Lab, UNC-Chapel Hill, Courtesy of Helen Willcockson
Substance P is a neuropeptide derived from preprotachinin. Substance P is widely distributed in the central and peripheral nervous system. In sensory ganglia, it is expressed by small sensory neurons and is transported to their central and peripheral terminals. The role of substance P in sensory transmission has been studied extensively, and its involvement in nociception and chronic pain is well established.